# A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks

@article{Schuster2000AGD, title={A general definition of metabolic pathways useful for systematic organization and analysis of complex metabolic networks}, author={Stefan Schuster and David A. Fell and Thomas Dandekar}, journal={Nature Biotechnology}, year={2000}, volume={18}, pages={326-332} }

A set of linear pathways often does not capture the full range of behaviors of a metabolic network. The concept of ‘elementary flux modes’ provides a mathematical tool to define and comprehensively describe all metabolic routes that are both stoichiometrically and thermodynamically feasible for a group of enzymes. We have used this concept to analyze the interplay between the pentose phosphate pathway (PPP) and glycolysis. The set of elementary modes for this system involves conventional… Expand

#### 959 Citations

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